While RCT design is scientifically robust, readily accepted, and historically verified, limiting ourselves too strictly to this approach will result in significant limitations to our collective progress. Using PCT principles to design nursing research studies generates results that are more actionable, patient-centered, and relevant. PCT research output is actionable because it is designed around pragmatic and realistic clinical settings and is focused on implementation. A PCT’s alignment of goals and measures around individuals’ goals of care and its pragmatic adaptation to non-response to interventions ensures a patient-centered process and results. The PCT data and results, along with adherence to practical settings and goals, produce results that are understandable, relatable, and relevant to health care decision-makers and policy proponents.