Purpose: This study aimed to evaluate the effects of health interventions using virtual reality (VR) on improving knowledge, attitudes, and
skills; and inducing behavioral change among adolescents. Methods: This study is a systematic review and meta-analysis following PRISMA
guidelines. We searched Cochrane, MEDLINE, Embase, CINAHL, Scopus, Web of Science, and Korean databases between database inception
and April 10, 2021. Based on heterogeneity, a random- or fixed-effects model was used, as appropriate, to calculate effect sizes in terms
of the standardized mean difference (SMD) and odds ratio (OR). Studies were selected if they verified the effects of health education using
VR on adolescents; there was an appropriate control group; and if the effects of education were reported in terms of changes in
knowledge, attitudes, skills, or behaviors. Results: This analysis included six studies (n = 1,086). The intervention groups showed greater responses
in knowledge and attitudes (SMD = 0.57, 95% confidence interval (CI) [0.12 to 1.02]), skills related to health behavior (SMD = -
0.45, 95% CI [- 0.71 to - 0.19]), and behavioral change after 12 months (OR = 2.36, 95% CI [1.03 to 5.41]). Conclusion: The results confirm
the effectiveness of health interventions using virtual reality (VR). Although the analysis include a small number of studies, a case can
be made for health interventions using VR to be utilized as educational methods and strategies to prevent risky behaviors among adolescents.